Despite the occurrence of approximately 10,000 transmetatarsal amputat
ions (TMAs) a year in the United States, there are few reports describ
ing rehabilitation for this patient group. The purposes of this clinic
al perspective are (1) to identify common problems encountered during
rehabilitation of patients with TMA, (2) to identify factors that may
contribute to these problems, and (3) to propose methods to manage the
se problems. A review of the literature and biomechanical models of th
e residuum, footwear, and orthotic devices are provided to help accomp
lish these purposes. Common problems encountered during rehabilitation
of patients with TMA are skin breakdown and instability during functi
onal activities. Decreased foot length and peripheral neuropathies app
ear to contribute to these problems. Solutions focus on attempting to
provide a substitute for the plantar-flexor lever arm and protection o
f the insensitive residual foot. Suggestions for additional research a
re presented.