LOSS OF HETEROZYGOSITY ON CHROMOSOME-22 IN OVARIAN-CARCINOMA IS DISTAL TO AND IS NOT ACCOMPANIED BY MUTATIONS IN NF2 AT 22Q12

Authors
ENGLEFIELD P FOULKES WD CAMPBELL IG
Citation
P. Englefield et al., LOSS OF HETEROZYGOSITY ON CHROMOSOME-22 IN OVARIAN-CARCINOMA IS DISTAL TO AND IS NOT ACCOMPANIED BY MUTATIONS IN NF2 AT 22Q12, British Journal of Cancer, 70(5), 1994, pp. 905-907
Citations number
32
Categorie Soggetti
Oncology
Journal title
British Journal of Cancer → ACNP
ISSN journal
00070920
Volume
70
Issue
5
Year of publication
1994
Pages
905 - 907
Database
ISI
SICI code
0007-0920(1994)70:5<905:LOHOCI>2.0.ZU;2-P
Abstract
Frequent loss of heterozygosity (LOH) has been reported on 22q in ovar ian carcinoma, implying the presence of a tumour-suppressor gene. The neurofibromatosis type 2 gene (NF2) at 22q12 is a plausible candidate. Analysis of 9 of the 17 exons of NF2 by single-strand conformational polymorphism (SSCP) in 67 ovarian carcinomas did not detect any somati c mutations, suggesting that NF2 is not involved in the pathogenesis o f ovarian carcinoma. LOH data support this conclusion and that the put ative tumour-suppressor gene lies distal to NF2, beyond D22S283.