CREATINE-KINASE ISOENZYME BB INCREASED IN SERUM AND TUMOR-TISSUE OF PATIENTS WITH GIANT-CELL TUMOR OF BONE

Citation
J. Fukuda et al., CREATINE-KINASE ISOENZYME BB INCREASED IN SERUM AND TUMOR-TISSUE OF PATIENTS WITH GIANT-CELL TUMOR OF BONE, Clinical chemistry, 40(11), 1994, pp. 2064-2065
Citations number
10
Categorie Soggetti
Chemistry Medicinal
Journal title
ISSN journal
00099147
Volume
40
Issue
11
Year of publication
1994
Part
1
Pages
2064 - 2065
Database
ISI
SICI code
0009-9147(1994)40:11<2064:CIBIIS>2.0.ZU;2-X
Abstract
Increased creatine kinase isoenzyme BB (CK-BB) has been observed in se ra from patients with brain injuries and occasionally in sera from pat ients with malignancy. We report here that, in two patients with giant cell tumor of bone (GCT), preoperative serum CK-BB increased to simil ar to 20 and 90 U/L, but in postoperative serum the CK-BB decreased to normal values. That the tumors contained CK-BB was indicated by elect rophoretic analysis and immunohistochemical staining. Furthermore, ser um CK-BB was detectable in five additional cases of GCT and in culture d tumor cells from a patient with GCT by an electrophoretic method. Th ese results suggest that CK-BB may be a marker for GCT.