J. Fukuda et al., CREATINE-KINASE ISOENZYME BB INCREASED IN SERUM AND TUMOR-TISSUE OF PATIENTS WITH GIANT-CELL TUMOR OF BONE, Clinical chemistry, 40(11), 1994, pp. 2064-2065
Increased creatine kinase isoenzyme BB (CK-BB) has been observed in se
ra from patients with brain injuries and occasionally in sera from pat
ients with malignancy. We report here that, in two patients with giant
cell tumor of bone (GCT), preoperative serum CK-BB increased to simil
ar to 20 and 90 U/L, but in postoperative serum the CK-BB decreased to
normal values. That the tumors contained CK-BB was indicated by elect
rophoretic analysis and immunohistochemical staining. Furthermore, ser
um CK-BB was detectable in five additional cases of GCT and in culture
d tumor cells from a patient with GCT by an electrophoretic method. Th
ese results suggest that CK-BB may be a marker for GCT.