In this study, 69 episodic cluster headache (CH) patients (40 in the a
ctive phase, 29 in remission period) underwent a complete TCD examinat
ion in order to verify the relationship between cerebral blood velocit
ies (CBVs) and the clinical profile of the disease. Fifteen patients w
ere examined during both phases, while 7 were monitored during a spont
aneous attack. Sixty-three healthy sex and age-matched controls were a
lso studied. We measured widespread, asymmetric CBV activation during
the active phase, bilaterally in the anterior circulation and also in
the post error circulation. A relative reduction of CBV on the anterio
r cerebral artery pain side, also during remission, suggests a relatio
nship between local vasodilation and the autonomic symptoms ipsilatera
l to pain during CH attacks.