CHOLINE-ACETYLTRANSFERASE ACTIVITY IS REDUCED IN RAT NUCLEUS-ACCUMBENS AFTER UNLIMITED ACCESS TO SELF-ADMINISTRATION OF COCAINE

Authors
WILSON JM CARROLL ME LAC ST DISTEFANO LM KISH SJ
Citation
Jm. Wilson et al., CHOLINE-ACETYLTRANSFERASE ACTIVITY IS REDUCED IN RAT NUCLEUS-ACCUMBENS AFTER UNLIMITED ACCESS TO SELF-ADMINISTRATION OF COCAINE, Neuroscience letters, 180(1), 1994, pp. 29-32
Citations number
20
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
180
Issue
1
Year of publication
1994
Pages
29 - 32
Database
ISI
SICI code
0304-3940(1994)180:1<29:CAIRIR>2.0.ZU;2-P
Abstract
Choline acetyltransferase (ChAT) activity was measured in discrete are as of rat brain after chronic, unlimited access to self-administration of cocaine. Mean activity of ChAT was reduced by approximately 30% in the nucleus accumbens, both on the last day of cocaine access and aft er 3 weeks cocaine withdrawal. These data suggest that chronic cocaine exposure might inhibit nucleus accumbens cholinergic neurones which c ould underlie some of the behavioral effects of cocaine.