EFFECT OF [DL]-ALPHA-TOCOPHEROL ON FECL2-INDUCED LIPID-PEROXIDATION IN RAT AMYGDALA

Authors
TRIGGS WJ WILLMORE LJ
Citation
Wj. Triggs et Lj. Willmore, EFFECT OF [DL]-ALPHA-TOCOPHEROL ON FECL2-INDUCED LIPID-PEROXIDATION IN RAT AMYGDALA, Neuroscience letters, 180(1), 1994, pp. 33-36
Citations number
36
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
180
Issue
1
Year of publication
1994
Pages
33 - 36
Database
ISI
SICI code
0304-3940(1994)180:1<33:EO[OFL>2.0.ZU;2-W
Abstract
Peroxidative injury of neural membrane lipids can be initiated by iron -containing blood products, chelated ferrous or ferric ions, and low v alence iron in aqueous solution. Lipid peroxidation was measured follo wing focal injection of 3 mu l of 100 mM FeCl2, into rat amygdala. Acu te parenteral administration of [dl]-alpha-tocopherol as the alcohol l imited the quantity of peroxidation products generated. These data sug gest a potential role for alpha-tocopherol administration in limiting brain injury responses.