APOLIPOPROTEIN-E (APOE), A NOVEL HEPARIN-BINDING PROTEIN INHIBITS THEDEVELOPMENT OF KAPOSIS SARCOMA-LIKE LESIONS IN BALB C NU/NU MICE/

Authors
BROWNING PJ ROBERTS DD ZABRENETZKY V BRYANT J KAPLAN M WASHINGTON RH PANET A GALLO RC VOGEL T
Citation
Pj. Browning et al., APOLIPOPROTEIN-E (APOE), A NOVEL HEPARIN-BINDING PROTEIN INHIBITS THEDEVELOPMENT OF KAPOSIS SARCOMA-LIKE LESIONS IN BALB C NU/NU MICE/, The Journal of experimental medicine, 180(5), 1994, pp. 1949-1954
Citations number
43
Categorie Soggetti
Immunology,"Medicine, Research & Experimental
Journal title
The Journal of experimental medicine → ACNP
ISSN journal
00221007
Volume
180
Issue
5
Year of publication
1994
Pages
1949 - 1954
Database
ISI
SICI code
0022-1007(1994)180:5<1949:A(ANHP>2.0.ZU;2-G
Abstract
Recombinant apolipoprotein E-3 (ApoE-3), expressed in Escherichia coli , was purified and used in an in vitro and an in vivo model system for acquired immunodeficiency syndrome-associated Kaposi's sarcoma (AIDS- KS). This protein blocked cell proliferation and chemotaxis of AIDS-KS cells in response to activated lymphocyte conditioned medium (AL-CM) and oncostatin M (OSM). ApoE-3 also inhibited the formation of neoangi ogenic lesions induced in BALB/c nu/nu mice by AIDS-KS cells. These fi ndings represent a novel and potentially less toxic therapeutic approa ch for the treatment of AIDS-KS.