P. Coussotrico et al., RELATION BETWEEN POLYHYDROXYALKANOATE MEM BRANE-SURFACE ENERGY AND PROTEIN ADSORPTION ON THESIS MEMBRANES, European Polymer Journal, 30(11), 1994, pp. 1327-1333
The haemocompatibility of a material can be evaluated through the stud
y of the adsorption of proteins stimulating the thrombus formation. Fi
lms of polyhydroxybutyrate (PHB) and copolymers thereof containing res
pectively 9% and 22% of hydroxyvalerate (HV) were treated by perfluoro
hexane (PHF) and PHF + H-2 plasmas to study protein adsorption. It has
been shown that hydrophobic polymer films adsorb more albumin than fi
brinogen. Moreover, the amounts of protein adsorbed seem to be mainly
a function of the surface roughness of the films, the highest amounts
being adsorbed on the rougher films (treated with PFH + H-2 plasma), w
hile the smoother PFH-treated surfaces adsorbed less proteins.