CONFORMATIONAL EFFECTS IN THE BIOLOGICAL-ACTIVITY OF FLUORINATED ANALOGS OF BETA-THUJAPLICIN

Authors
MURATA K KITAZUME T
Citation
K. Murata et T. Kitazume, CONFORMATIONAL EFFECTS IN THE BIOLOGICAL-ACTIVITY OF FLUORINATED ANALOGS OF BETA-THUJAPLICIN, Journal of fluorine chemistry, 69(2), 1994, pp. 129-131
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear
Journal title
Journal of fluorine chemistry → ACNP
ISSN journal
00221139
Volume
69
Issue
2
Year of publication
1994
Pages
129 - 131
Database
ISI
SICI code
0022-1139(1994)69:2<129:CEITBO>2.0.ZU;2-W
Abstract
Fluorination of beta-thujaplicin with diethylaminosulfur trifluoride ( DAST) gave 2-fluoro-4-isopropyltropone and 2-fluoro-6-isopropyltropone (1:1 mixture; 60%). The relationships between the antibacterial activ ities and conformations of beta-thujaplicin and its fluorinated analog s are discussed.