PROTECTIVE EFFECT OF SOME EXOGENOUS GLYCOLIPIDS ON HUMAN CULTURED KERATINOCYTES AGAINST LIPID-PEROXIDATION

Authors
VARANI I TERZAGHI A DONATI L MARAZZI M MASSERINI M TETTAMANTI G
Citation
I. Varani et al., PROTECTIVE EFFECT OF SOME EXOGENOUS GLYCOLIPIDS ON HUMAN CULTURED KERATINOCYTES AGAINST LIPID-PEROXIDATION, Archives of dermatological research, 286(8), 1994, pp. 481-483
Citations number
20
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
Archives of dermatological research → ACNP
ISSN journal
03403696
Volume
286
Issue
8
Year of publication
1994
Pages
481 - 483
Database
ISI
SICI code
0340-3696(1994)286:8<481:PEOSEG>2.0.ZU;2-P
Abstract
Cultured human keratinocytes were incubated in the presence of glycoli pids (GM1, asialoGM1, glucosylceramide and galactosylceramide) added t o the medium at a concentration of 10(-5)M. All of them became associa ted with the cells, but in different amounts depending on the type of glycolipid and on the time in culture. GM1- and asialoGM1-treated kera tinocytes developed a resistance to peroxidative stress induced by FeS O4/H2O2 treatment. These results suggest that these exogenously added glycolipids could play a role as eutrophic, repairing and protective a gents for the epidermis.