IMPROVED SURVIVAL WITH PERCUTANEOUS ETHANOL INJECTION IN PATIENTS WITH LARGE HEPATOCELLULAR-CARCINOMA

Objective: To evaluate the efficacy of percutaneous ethanol injection in the management of patients with large hepatocellular carcinoma. Des ign: Prospective controlled study. Ten patients were randomized to rec eive percutaneous ethanol injection and five served as controls. Setti ng: Tertiary hospital. Participants: Fifteen patients with large (>5 c m) lesions with or without cirrhosis and no ascites. Mean tumour size in the percutaneous ethanol injection group (82.5+/-59 cm2) and in the control group (87.1+/-58 cm2) was comparable. Intervention: Percutane ous ethanol injection was performed under ultrasound guidance. Repeate d injections (mean 5.1+/-1.6 sessions) were given and a mean 38.8+/-8. 3 ml ethanol was injected per patient until the lesion appeared 'marbl e like' at ultrasound. Results: There was a significant (P<0.01) decre ase in the median tumour size (median 14%; range, 0-68%) in nine of th e 10 patients compared with a 20% increase in size in the untreated pa tients. Median survival in the percutaneous ethanol injection group wa s 9 months (range, 4-38 months) and 5 months in the control group (ran ge, 1-8 months); the difference was significant (P<0.05). Conclusions: Percutaneous ethanol injection is a safe and effective technique whic h arrests tumour growth, may decrease tumour size and can improve surv ival in patients with large hepatocellular carcinoma.