Eb. Kaplan et al., LATE EFFECTS OF BONE-MARROW TRANSPLANTATION ON PULMONARY-FUNCTION IN CHILDREN, Bone marrow transplantation, 14(4), 1994, pp. 613-621
This study was undertaken to evaluate in a primarily pediatric populat
ion whether the late effects of bone marrow transplantation (BMT) on p
ulmonary function in patients having undergone the procedure for treat
ment of acute leukemia or lymphoma are worse than that of patients hav
ing undergone transplant for treatment of aplastic anemia. Forty-six p
atients were studied. We did not demonstrate statistically significant
differences in group mean forced expiratory flow in one second/forced
vital capacity (FEV(1)/FVC) and percentage predicted forced expirator
y volume in one second (FEV(1)), forced vital capacity (FVC), forced e
xpiratory flow at 25-75% of the forced vital capacity (FEF(25-75)) and
total lung capacity (TLC) values between the two groups of patients b
efore BMT and to 7 years post-transplant. Individual patients with pul
monary function abnormalities were identified. Furthermore, there were
no significant differences between the two study groups or within the
group of patients with aplastic anemia from pre-transplant to 9-12 mo
nths and from pre-transplant to 18-24 months after BMT. However, withi
n the group of patients treated for acute leukemia or lymphoma, there
was a significant decline in the group mean percentage predicted FVC (
p = 0.0001), FEV(1) (p = 0.0006) and FEF(25-75) (p = 0.0063) from pre-
transplant to 9-12 months and in the FVC (p = 0.004) and FEV(1) (p = 0
.0006) from pre-transplant to 18-24 months after BMT. The greater decl
ine in the FVC relative to the FEV(1) suggests the development of a re
strictive process in this group of patients.