Ey. Sozmen et al., ETHANOL-INDUCED OXIDATIVE STRESS AND MEMBRANE INJURY IN RAT ERYTHROCYTES, European journal of clinical chemistry and clinical biochemistry, 32(10), 1994, pp. 741-744
The aim of this study was to observe membrane injury and to investigat
e the mechanism of antioxidant defence systems against acute ethanol t
oxicity. Erythrocyte superoxide dismutase and Na+, K+-ATPase activitie
s were significantly decreased and catalase levels were significantly
increased one hour after ethanol intoxication of male swiss albino rat
s. These data demonstrated that superoxide dismutase and catalase are
susceptible to lipid peroxidation and that these enzymes protect tissu
es from free radicals. The possible mechanism involved in Na+ K+-ATPas
e and Ca2+-ATPase inhibition are discussed in relation to the developm
ent of ethanol toxicity and the role of lipid peroxidative processes.