EFFECT OF DIPYRIDAMOLE ON THE BLOOD-FLOW IN CORONARY ANEURYSMS RESULTING FROM KAWASAKI-DISEASE

Dipyridamole has been widely used in Japan to treat patients with a co ronary aneurysm resulting from Kawasaki disease, but its effect in the se patients has not been established. In the present study we assessed the effect of dipyridamole on the coronary arteries of patients with a history of Kawasaki disease by measuring the diameter of the coronar y arteries and by quantifying the disappearance time of contrast mediu m (runoff time) on coronary angiography. Intravenous injection of dipy ridamole increased the diameter of nondilated arteries by 7.9%. Its ef fect on the diameter of dilated coronary arteries (coronary aneurysm) was less than 3% (p < 0.01). Runoff time of dilated coronary arteries was significantly (p < 0.01) greater than that of nondilated coronary arteries. Dipyridamole accelerated runoff time not only in nondilated coronary arteries (p < 0.01) but also in coronary arteries with variou s degrees of dilatation (p < 0.01). We conclude that dipyridamole incr eases blood flow in coronary arteries without dilating the proximal an eurysm in children with a history of Kawasaki disease.