SYNTHESIS, RADIOLABELING AND STABILITY OF RADIOIODINATED M-IODOBENZYLGUANIDINE, A REVIEW

Authors
WAFELMAN AR KONINGS MCP HOEFNAGEL CA MAES RAA BEIJNEN JH
Citation
Ar. Wafelman et al., SYNTHESIS, RADIOLABELING AND STABILITY OF RADIOIODINATED M-IODOBENZYLGUANIDINE, A REVIEW, Applied radiation and isotopes, 45(10), 1994, pp. 997-1007
Citations number
56
Categorie Soggetti
Nuclear Sciences & Tecnology","Radiology,Nuclear Medicine & Medical Imaging
Journal title
Applied radiation and isotopes
ISSN journal
09698043 → ACNP
Volume
45
Issue
10
Year of publication
1994
Pages
997 - 1007
Database
ISI
SICI code
0969-8043(1994)45:10<997:SRASOR>2.0.ZU;2-#
Abstract
Since the introduction of radioiodinated m-iodobenzylguanidine in 1980 , much research has been performed, both in the chemical field as well as in medical sciences. This paper reviews the synthesis, radiolabell ing and stability of radioiodinated m-iodobenzylguanidine. Regarding t he many radiolabelling procedures for m-iodobenzylguanidine, the Cu1+- assisted nucleophilic exchange radioiodination can be considered as th e method of first choice. Quality control of the radiopharmaceutical p roduct is discussed and attention is paid to recent studies regarding the radiochemical stability of iodine-131 labelled m-iodobenzylguanidi ne.