BRONCHOCENTRIC GRANULOMATOSIS AND CENTRAL DIABETES-INSIPIDUS SUCCESSFULLY TREATED WITH CORTICOSTEROIDS

Bronchocentric granulomatosis (BCG) is a rare chronic granulomatous lu ng disease that leads to destruction of the airway walls. It has been observed in association with various conditions, but never, so far, be en reported to involve the central nervous system. We report a case of histologically confirmed pulmonary bronchocentric granulomatosis temp orally associated with a partial central diabetes insipidus (CDI). Alt hough the pathological basis of the posterior pituitary gland involvem ent was not ascertained, the temporal association of bronchocentric gr anulomatosis and central diabetes insipidus, as well as the fact that corticosteroid treatment provided stable remission of both conditions after a 10 month follow-up, strongly suggest that central diabetes ins ipidus was aetiologically related to bronchocentric granulomatosis in this patient.