EFFECT OF SUBACUTE TOLUENE ADMINISTRATION ON THE ENKEPHALINERGIC NEUROMODULATORY SYSTEM IN RATS AND PROTECTIVE ACTION OF GANGLIOSIDE TREATMENTS

Authors
DEGANDARIAS JM ECHEVARRIA E SERRANO R IRAZUSTA J CASIS L
Citation
Jm. Degandarias et al., EFFECT OF SUBACUTE TOLUENE ADMINISTRATION ON THE ENKEPHALINERGIC NEUROMODULATORY SYSTEM IN RATS AND PROTECTIVE ACTION OF GANGLIOSIDE TREATMENTS, Toxicology and industrial health, 10(3), 1994, pp. 155-161
Citations number
20
Categorie Soggetti
Toxicology,"Public, Environmental & Occupation Heath
Journal title
Toxicology and industrial health → ACNP
ISSN journal
07482337
Volume
10
Issue
3
Year of publication
1994
Pages
155 - 161
Database
ISI
SICI code
0748-2337(1994)10:3<155:EOSTAO>2.0.ZU;2-2
Abstract
Gangliosides perform protective functions in the central nervous syste m. This paper describes a study of the effect of ganglioside administr ation on toluene neurotoxicity. Rat brain met-enkephalin immunostainin g in the central amygdaloid nuclei showed changes in rats treated simu ltaneously with gangliosides and toluene with respect to rats treated with toluene alone. It is suggested that gangliosides prevent toluene neurotoxicity at this level, leading to hypothetical neurobehavioral c hanges.