REACTIVATION OF ANTIBODIES OF DONOR AND RECIPIENT ORIGIN TO PLATELET ANTIGENS EARLY AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION - A CASE-REPORT

Authors
WERNET D NORTHOFF H SCHNAIDT M
Citation
D. Wernet et al., REACTIVATION OF ANTIBODIES OF DONOR AND RECIPIENT ORIGIN TO PLATELET ANTIGENS EARLY AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION - A CASE-REPORT, British Journal of Haematology, 88(3), 1994, pp. 615-617
Citations number
9
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
88
Issue
3
Year of publication
1994
Pages
615 - 617
Database
ISI
SICI code
0007-1048(1994)88:3<615:ROAODA>2.0.ZU;2-W
Abstract
Reactivation of platelet-reactive antibodies of donor and recipient or igin is described in a patient following allogeneic BMT (donor: anti-H PA-5b; recipient: anti-HLA, anti-HPA-1b). The antibodies were detected around day 15 after BMT, peaked around day 25, and then decreased. Th ese antibodies are interpreted as an antigen-independent reactivation of secondary B-cell responses, activated in the context of recognition of host antigens by the graft.