TREATMENT OF CHRONIC CHILDHOOD IMMUNE THROMBOCYTOPENIC PURPURA WITH INTRAMUSCULAR ANTI-D IMMUNOGLOBULINS

Seven patients with chronic immune thrombocytopenic purpura (ITP) were treated with intramuscular anti-D (anti-D IgG) five times, on an alte rnate-day basis, or until a platelet count of 100 x 10(9)/l was achiev ed and subsequently, when necessary to maintain platelet counts above 50 x 10(9)/l. Five patients responded to therapy, two of whom entered long-term remission. although signs of haemolysis were present in all patients, anaemia was never a problem. No patient developed haematomas at the site of injection. We suggest that intramuscular anti-D repres ents a safe and relatively inexpensive alternative to intravenous gamm a globulins (IVGG) for children with severe chronic ITP.