EPSTEIN-BARR-VIRUS IN FAMILIAL HODGKINS-DISEASE

Authors
SCHLAIFER D RIGALHUGUET F ROBERT A ATTAL M ABBAL M FONCK Y LAURENT G PRIS J DELSOL G BROUSSET P
Citation
D. Schlaifer et al., EPSTEIN-BARR-VIRUS IN FAMILIAL HODGKINS-DISEASE, British Journal of Haematology, 88(3), 1994, pp. 636-638
Citations number
12
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
88
Issue
3
Year of publication
1994
Pages
636 - 638
Database
ISI
SICI code
0007-1048(1994)88:3<636:EIFH>2.0.ZU;2-4
Abstract
Hodgkin's disease (HD) has been found to be linked to Epstein-Barr vir us (EBV). Familia HD (FHD) may be related to a possible unknown agent. We have determined whether EBV small RNAs (EBERs) were found in Reed- Sternberg cells from FHD. Five families were studied for histological subtype and EBER presence. There was a striking similarity in FHD subt ypes of each family and 3/11 (27%) of the cases were EBER positive. In conclusion, EBV EBERs are only infrequently found in FHD and other fa ctors including viruses different from EBV should be further investiga ted in FHD.