SELECTIVE INHIBITORS OF PROTEIN-KINASE-C IN A MODEL OF GRAFT-VS-HOST DISEASE

Authors
DEMERS JP HAGEMAN WE JOHNSON SG KLAUBERT DH LOOK RA MOORE JB
Citation
Jp. Demers et al., SELECTIVE INHIBITORS OF PROTEIN-KINASE-C IN A MODEL OF GRAFT-VS-HOST DISEASE, Bioorganic & medicinal chemistry letters, 4(20), 1994, pp. 2451-2456
Citations number
39
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
20
Year of publication
1994
Pages
2451 - 2456
Database
ISI
SICI code
0960-894X(1994)4:20<2451:SIOPIA>2.0.ZU;2-3
Abstract
A series of 3-aryl-4-arylidene-5-isoxazolones were found to be active as inhibitors of PKC, and in ex-vivo and in vivo models of graft-versu s-host disease.