SYNTHESIS AND NEURAMINIDASE INHIBITION STUDIES OF 4-AZIDO, AMINO, ANDACETAMIDO SUBSTITUTED SIALOSIDES

Authors
SABESAN S
Citation
S. Sabesan, SYNTHESIS AND NEURAMINIDASE INHIBITION STUDIES OF 4-AZIDO, AMINO, ANDACETAMIDO SUBSTITUTED SIALOSIDES, Bioorganic & medicinal chemistry letters, 4(20), 1994, pp. 2457-2460
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
20
Year of publication
1994
Pages
2457 - 2460
Database
ISI
SICI code
0960-894X(1994)4:20<2457:SANISO>2.0.ZU;2-S
Abstract
Synthesis of 4-azido-NeuAc containing sialosides and thiosialosides ha s been developed via the hydrochlorination of an 4-azidoglycal. The az idosialosides have been converted into the amino and acetamidosialosid es. Two of the aminosialosides show potent inhibition (K-i = 50-150 mu M) of influenza neuraminidase.