HYPHODONTAL, A NEW ANTIFUNGAL INHIBITOR OF REVERSE TRANSCRIPTASES FROM HYPHODONTIA SP (CORTICIACEAE, BASIDIOMYCETES)

Authors
ERKEL G ANKE T VELTEN R GIMENEZ A STEGLICH W
Citation
G. Erkel et al., HYPHODONTAL, A NEW ANTIFUNGAL INHIBITOR OF REVERSE TRANSCRIPTASES FROM HYPHODONTIA SP (CORTICIACEAE, BASIDIOMYCETES), Zeitschrift fur Naturforschung. C, A journal of biosciences, 49(9-10), 1994, pp. 561-570
Citations number
24
Categorie Soggetti
Biology
Journal title
Zeitschrift fur Naturforschung. C, A journal of biosciences → ACNP
ISSN journal
09395075
Volume
49
Issue
9-10
Year of publication
1994
Pages
561 - 570
Database
ISI
SICI code
0939-5075(1994)49:9-10<561:HANAIO>2.0.ZU;2-R
Abstract
In a search for inhibitors of RNA-directed DNA polymerases a new isola ctarane sesquiterpenoid, hyphodontal (1), was isolated from fermentati ons of a Canadian Hyphodontia species. Its structure was elucidated by spectroscopic methods. Hyphodontal strongly inhibits the growth of se veral yeasts and is a non-competitive inhibitor of avian myeloblastosi s virus (K-i 346 mu M) and Moloney murine leukemia virus (K-i 112 mu M ) reverse transcriptases. In addition, cytotoxic and antifungal activi ties were observed.