SIMULTANEOUS OCCURRENCE OF ADENOMAS IN STOMACH, DUODENAL BULB, AND COLON - DISAPPEARANCE OF GASTRIC AND DUODENAL ADENOMAS DURING ORAL-ADMINISTRATION OF 5'-DEOXY-5-FLUOROURIDINE

The present report concerns a patient who was first diagnosed as havin g adenoma in the duodenal bulb and subsequently was discovered to have adenomas in the stomach and colon. Surgical procedures including endo scopic resection could not be carried out because the patient had adva nced liver cirrhosis. Follow-up colonoscopy no longer detected any pol yp in the colon. Ultrasonography demonstrated a slowly growing hypoech oic. mass in the liver, which was indicative of hepatocellular carcino ma. Then, single chemotherapy with oral administration of 5'-deoxy-5-f luorouridine was initiated. Surprisingly, repeated esophagogastroduode noscopy revealed gradual regression of the gastric and duodenal tumors . Findings from the endoscopy and biopsy materials 10 months after the start of therapy showed disappearance of the gastric and duodenal ade nomas. Despite enlargement of the hepatic mass, no recurrence of gastr ic and duodenal tumors has been noted during the past 11/2 yr.