SYNTHESIS OF BAPTA-AM ANALOGS CAPABLE OF ENHANCING THE VASCULAR PRODUCTION OF PROSTACYCLIN

Authors
HEILPORN S BROEDERS F DALOZE D BRAEKMAN JC BOEYNAEMS JM
Citation
S. Heilporn et al., SYNTHESIS OF BAPTA-AM ANALOGS CAPABLE OF ENHANCING THE VASCULAR PRODUCTION OF PROSTACYCLIN, Bulletin des Societes chimiques belges, 103(7-8), 1994, pp. 309-319
Citations number
9
Categorie Soggetti
Chemistry
Journal title
Bulletin des Societes chimiques belges → ACNP
ISSN journal
00379646
Volume
103
Issue
7-8
Year of publication
1994
Pages
309 - 319
Database
ISI
SICI code
0037-9646(1994)103:7-8<309:SOBACO>2.0.ZU;2-2
Abstract
About 30 analogues of BAPTA-AM, a potential antithrombotic agent, have been synthesized and tested for their effect on the production of pro stacyclin. None of them was found to be a better enhancer of the produ ction of prostacyclin by aortic endothelial cells than BAPTA-AM itself . The enhancing effect can be produced by compounds unable to chelate Ca2+, thus confirming that it is not related to their buffering capaci ty for free Ca2+.