R. Fogari et al., ENDOTHELIN IN MILD-TO-MODERATE ESSENTIAL-HYPERTENSION - RELATIONSHIP BETWEEN AMBULATORY AND CLINIC BLOOD-PRESSURE VALUES, Journal of human hypertension, 8(10), 1994, pp. 761-764
We investigated in a post hoc analysis the relationship between plasma
endothelin (ET-1) levels (immunoreactive ET-1-like material: ir-ET-1)
with both casual and noninvasive 24h ambulatory blood pressure monito
ring (24h ABPM) values in EH. Fifteen uncomplicated EH patients (casua
l supine DBP greater-than-or-equal-to 100 mmHg), 10 males, age 54 +/-
6 years, 13 previously treated, enrolled in an antihypertensive drug t
rial (casual DBP greater-than-or-equal-to 100 mmHg), were evaluated. A
fter a four week single-blind placebo wash-out period, measurements of
supine casual SBP and DBP (three consecutive readings) and a 24h ABPM
(Spacelabs 90207; automatic reading every 15 minutes) were carried ou
t. Plasma ir-ET-1 was measured by radioimmunoassay kit (Amersham, UK).
Pearson correlation coefficient tests were used for statistical evalu
ations. Mean (SD) casual SBP/DBP values were 166(5)/104(2) mmHg. The 2
4h ABPM mean values were 148(7)/87(3) mmHg. Daytime (07.00-23.00h) and
nighttime (23.00-07.00h) SBP/DBP were 153(7)/91(3) and 137(10)/78(5)
mmHg, respectively. Plasma ir-ET-1 levels were 0.9(0.5) pmol/l (range
0.3-2.1 pmol/l). Plasma ir-ET-1 was not correlated with casual SBP and
DBP, age, serum creatinine and duration of EH. Positive and significa
nt correlations were observed with 24h SBP (r = 0.59), daytime SBP (r
= 0.58), nighttime SBP (r = 0.53) and DBP (r = 0.60). Unlike casual BP
, ABPM mean values correlate positively with plasma ir-ET-1 in mild to
moderate EH.