Medetomidien 10 mug/kg, was combined with butorphanol 0.1 mg/kg and ad
ministered intramuscularly to 27 dogs requiring sedation for various d
iagnostic or therapeutic procedures. All the dogs became deeply sedate
d. Heart rate fell by a mean of 55 per cent. Eighteen dogs showed sign
s of pain as the combination was injected. Sedation was sufficient for
the intended procedure to be carried out in 25 of the dogs. General a
naesthesia was induced in four dogs - the mean dose of thiopentone req
uired for induction of anaesthesia was 2 mg/kg. Administration of atip
amezole at the end of the procedure produced rapid and sudden recoveri
es in all the dogs, with a mean time to standing of nine minutes.