ONE-STEP PREPARATION OF [2,3-H-3]1-AMINOCYCLOPROPANECARBOXYLIC ACID -A USEFUL LIGAND FOR STRYCHNINE-INSENSITIVE GLYCINE RECEPTORS

Authors
LEWIN AH LAMB PB POPIK P SKOLNICK P
Citation
Ah. Lewin et al., ONE-STEP PREPARATION OF [2,3-H-3]1-AMINOCYCLOPROPANECARBOXYLIC ACID -A USEFUL LIGAND FOR STRYCHNINE-INSENSITIVE GLYCINE RECEPTORS, Journal of labelled compounds & radiopharmaceuticals, 34(11), 1994, pp. 1063-1068
Citations number
8
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
34
Issue
11
Year of publication
1994
Pages
1063 - 1068
Database
ISI
SICI code
0362-4803(1994)34:11<1063:OPO[A->2.0.ZU;2-L
Abstract
Catalytic hydrogenation of 1-aminocyclopropenecarboxylic acid under tr itium gas afforded [2,3-H-3]1-aminocyclopropanecarboxylic acid with sp ecific activity 26 Ci/mmol, determined by a combination of H-1 and H-3 NMR. Pilot radioligand binding assays indicate this compound will be a useful probe for the NMDA receptor-associated strychnine-insensitive glycine receptor.