SYNTHESIS AND STABILITY OF [1,3-C-14(2)]-GLYCERYL TRINITRATE

The synthesis of [1,3-C-14(2)]-glyceryl trinitrate ([C-14]-GTN) labell ed with quasi carrier free carbon-14 atom in the 1,3-positions of the molecule was effected in four reaction steps from (CO2)-C-14 (3,5 % ov erall yield). The chemical and radiochemical purity of [C-14]-GTN was found better than 99% controlled by HPLC-Radioactivity Monitor and TLC -Digital Autoradiograph methods. Study of the radiochemical stability in dilute solution at 5 degrees C shows that the product can be stored at least for a month without detectable decomposition.