The stepwise synthesis of novel lipophilic, optically active macrocycl
ic crown ethers (S,S,S,S)-5, 6, 8 and 9, with four chiral centers of t
he same configuration and two 1,2,4-triazole subunits, starting from r
eadily accessible chiral 3,5-disubstituted 1,2,4-triazoles (S,S)-2 is
reported.