We present a case of recurrent meconium peritonitis detected in the se
cond trimester and treated by intrauterine intervention. Antenatal ult
rasound findings included fetal ascites and intra-abdominal calcificat
ion. Aspiration of fetal ascites under ultrasound guidance and determi
nation of the bilirubin concentration established the diagnosis of mec
onium peritonitis. Paracentesis was repeated to remove irritating inte
stinal contents and to decrease pressure on the fetal thorax. Although
the exact cause of the meconium peritonitis remains unknown, the recu
rrence of the condition suggests a genetic basis. A possibility of cys
tic fibrosis was not considered because the clinical picture did not s
uggest it. Intrauterine intervention helped to establish the diagnosis
of meconium peritonitis and may have contributed to the good outcome.