EFFECT OF POLY(I) POLY(C12U) (AMPLIGEN) ON ENTERIC VIRUS (ROTAVIRUS, POLIOVIRUS AND COXSACKIE B3 VIRUS) INFECTIONS

Authors
KONISHI K MUKOYAMA A MULLER WEG YAMAZAKI S USHIJIMA H
Citation
K. Konishi et al., EFFECT OF POLY(I) POLY(C12U) (AMPLIGEN) ON ENTERIC VIRUS (ROTAVIRUS, POLIOVIRUS AND COXSACKIE B3 VIRUS) INFECTIONS, Letters in applied microbiology, 19(5), 1994, pp. 386-390
Citations number
13
Categorie Soggetti
Microbiology,"Biothechnology & Applied Migrobiology
Journal title
Letters in applied microbiology → ACNP
ISSN journal
02668254
Volume
19
Issue
5
Year of publication
1994
Pages
386 - 390
Database
ISI
SICI code
0266-8254(1994)19:5<386:EOPP(O>2.0.ZU;2-4
Abstract
The effects of poly(I).poly(C12U) (Ampligen) on infections with enteri c viruses (rotavirus, poliovirus and Coxsackie B3 virus) were studied in vitro. Ampligen exhibited antiviral activity against rotavirus, esp ecially when treatment was performed prior to inoculation of the virus . It was partially effective against Coxsackie B3 virus, but not again st poliovirus. It is suggested that the observed effects may be due to the production of interferon induced by Ampligen.