ANTIMICROBIAL PROPHYLAXIS WITH CEFTRIAXONE IN RENAL-TRANSPLANTATION -PROSPECTIVE-STUDY OF 170 PATIENTS

Due to their uremic state and altered host response induced by immunod epressive therapy, renal transplant recipients are particularly suscep tible to infectious complications with high morbidity and mortality. W e here report the results of a prospective study with 170 renal transp lant patients, undertaken to evaluate the efficacy of ceftriaxone in t he prevention of wound and early urinary tract infection. No wound inf ection was observed, however, 12 patients (7.1%) developed urinary tra ct infections. On the basis of these data, we recommend ceftriaxone pr ophylaxis as a safe and effective measure to prevent transplant wound infection and to reduce the incidence of postoperative urinary tract i nfection.