PYRIDOXINE NEUROPATHY

Daily needs of vitamin B6 are very low (2 mg per day) and widely cover ed by normal feeding. Pyridoxine deficiencies are exceptionnal (congen ital metabolic abnormalities, drug or toxic - induced perturbations). First described in animal models, human cases of neuropathy had been e ncountered in the ''megavitamin'' - syndrome. They are confirmed by ra re case-reports of very high doses given in toxic indication. Sensory peripheral neuropathies can also occur with lower doses taken over a l ong period of time.