SUSCEPTIBILITY IN CELL-CULTURE OF FELINE IMMUNODEFICIENCY VIRUS TO 18ANTIVIRAL AGENTS

Authors
SMYTH NR MCCRACKEN C GASKELL RM CAMERON JM COATES JAV GASKELL CJ HART CA BENNETT M
Citation
Nr. Smyth et al., SUSCEPTIBILITY IN CELL-CULTURE OF FELINE IMMUNODEFICIENCY VIRUS TO 18ANTIVIRAL AGENTS, Journal of antimicrobial chemotherapy, 34(4), 1994, pp. 589-594
Citations number
11
Categorie Soggetti
Microbiology,"Pharmacology & Pharmacy
Journal title
Journal of antimicrobial chemotherapy → ACNP
ISSN journal
03057453
Volume
34
Issue
4
Year of publication
1994
Pages
589 - 594
Database
ISI
SICI code
0305-7453(1994)34:4<589:SICOFI>2.0.ZU;2-T
Abstract
The in-vitro susceptibilities of two strains of feline immunodeficienc y virus to 18 antiviral agents were determined in two cell lines. In t erms of inhibiting p24 antigen production, the nucleoside-analogue rev erse transcriptase inhibitors were the most effective compounds. Inhib ition was also observed with aurintricarboxylic acid, phosphonoformate and butyldeoxynorjirimycin, but not with the other agents tested.