ONCOGENE-TRANSFORMED RENAL-CELL LINES - PHYSIOLOGICAL AND ONCOGENETICSTUDIES

Use of inducible oncogenes has recently boosted interest in immortaliz ed cell lines derived by transfection of primary cultures or from tran sgenic mice. When the oncogene is functional, cells exhibit a transfor med phenotype, whereas, upon oncogene inactivation, they can different iate up to the level of the parental cells.