COMPARATIVE MAPPING OF THE IMPRINTED U2AFBPL GENE ON MOUSE CHROMOSOME-11 AND HUMAN-CHROMOSOME-5

The genetic map location of the recently discovered imprinted gene U2a fbpL has been verified and refined in several mouse crosses. RI strain analysis had previously shown that the gene is located on mouse chrom osome 11. This assignment has been verified using interspecific backcr osses. Moreover, the location of the gene relative to a fixed order of markers in the proximal region of mouse chromosome 11 has been establ ished. The location of the gene on mouse chromosome 11 corresponds to a homologous linkage group that is conserved on human chromosome 5q. T he location of the human homologue has been determined using both soma tic cell hybrid genetic analysis and fluorescence in situ hybridizatio n. These analyses have mapped the human locus U2AFBPL to human chromos ome 5q23-->q31.