ASSIGNMENT OF THE HUMAN HEART TETRODOTOXIN-RESISTANT VOLTAGE-GATED NA-SUBUNIT GENE (SCN5A) TO BAND 3P21( CHANNEL ALPHA)

Authors
GEORGE AL VARKONY TA DRABKIN HA HAN J KNOPS JF FINLEY WH BROWN GB WARD DC HAAS M
Citation
Al. George et al., ASSIGNMENT OF THE HUMAN HEART TETRODOTOXIN-RESISTANT VOLTAGE-GATED NA-SUBUNIT GENE (SCN5A) TO BAND 3P21( CHANNEL ALPHA), Cytogenetics and cell genetics, 68(1-2), 1995, pp. 67-70
Citations number
19
Categorie Soggetti
Cytology & Histology","Genetics & Heredity
Journal title
Cytogenetics and cell genetics → ACNP
ISSN journal
03010171
Volume
68
Issue
1-2
Year of publication
1995
Pages
67 - 70
Database
ISI
SICI code
0301-0171(1995)68:1-2<67:AOTHHT>2.0.ZU;2-6
Abstract
The chromosomal location of SCN5A, the gene encoding the principal vol tage-gated Na+ channel expressed in human heart, has been determined b y three independent methodologies: somatic cell hybrid mapping, chromo somal microdissection-polymerase chain reaction, and fluorescence in s itu hybridization. The SCN5A gene was assigned to the short arm of chr omosome 3 (band 3p21) by all three approaches. These data are further evidence that striated muscle Na+ channel genes are dispersed in the g enome.