CLINICAL AND LABORATORY OBSERVATIONS - LSD FLASHBACK SYNDROME EXACERBATED BY SELECTIVE SEROTONIN REUPTAKE INHIBITOR ANTIDEPRESSANTS IN ADOLESCENTS

Two adolescents with a long history of abuse of lysergic acid diethyla mide (LSD) and symptoms consistent with major depressive disorder, on initiation of antidepressant therapy with selective serotonin reuptake inhibitor agents, had the new onset or worsening of LSD flashback syn drome. The similarity in neuroreceptor physiology for both LSD and ser otonin suggests that the LSD flashback syndrome may be induced by thes e drugs in patients with a history of LSD abuse.