Using positron emission tomography (PET), thirteen studies of regional
brain glucose utilization were performed in 12 patients with postanox
ic syndrome due to cardiac arrest. Investigations were carried out at
least one month after brain anoxia. Seven subjects were in a persisten
t vegetative state. The others had regained normal consciousness with
various residual neurological signs. When compared with normal values
obtained in 16 normal, age-matched subjects, mean cerebral glucose met
abolism was drastically decreased (+/- 50%) in vegetative cases, and t
o a lesser degree (+/- 25%) in conscious subjects. The most consistent
regional alterations were observed in the parieto-occipital cortex (9
cases), the frontier between vertebral and carotid arterial territori
es. Other selective anomalies were found in the frontomesial junction
(5 cases), the striatum (3 cases with dystonia), and the visual cortex
(2 cases with cortical blindness). This study suggests that cerebral
anoxia results in a global brain hypometabolism, which appears related
to the vigilance state, as well as in regional disturbances preferent
ially located in arterial border zones. Although our findings remain t
o be confirmed in larger series, they suggest that PET provides a usef
ul index of residual brain tissue function after anoxia and may assist
in the monitoring of postanoxic encephalopathies.