BUDD-CHIARI SYNDROME AND EPSTEIN-BARR-VIRUS (EBV) ASSOCIATED PLASMACYTOMA IN A PATIENT WITH CHRONIC ACTIVE EBV INFECTION

Authors
NAGAFUCHI S ISHIBASHI H ANZAI K OHSHIMA K OHNO Y FUKUSHIMA N HASHIZUME M SUGIMACHI K CHUMAN H KIKUCHI M NIHO Y
Citation
S. Nagafuchi et al., BUDD-CHIARI SYNDROME AND EPSTEIN-BARR-VIRUS (EBV) ASSOCIATED PLASMACYTOMA IN A PATIENT WITH CHRONIC ACTIVE EBV INFECTION, The Clinical investigator, 72(11), 1994, pp. 883-886
Citations number
16
Categorie Soggetti
Medicine, General & Internal
Journal title
The Clinical investigator → ACNP
ISSN journal
09410198
Volume
72
Issue
11
Year of publication
1994
Pages
883 - 886
Database
ISI
SICI code
0941-0198(1994)72:11<883:BSAE(A>2.0.ZU;2-W
Abstract
A 42-year-old Japanese man with chronic active Epstein-Barr virus (EBV ) infection initially responded to treatment with interleukin-2 (IL-2) . Six months later he developed thrombosis in the hepatic veins, and B udd-Chiari syndrome associated with severe hepatic damage was diagnose d. He also developed a solitary EBV-positive plasmacytoma in the right femur. Since these rare complications occurred after long-term IL-2 t herapy, the possibility that long-term IL-2 therapy might cause Budd-C hiari syndrome and liver damage as well as EBV-associated plasmacytoma is discussed.