IMMUNOGENICITY OF THE ESCHERICHIA-COLI FIMBRIAL ANTIGEN K99 WHEN EXPRESSED BY SALMONELLA-ENTERITIDIS 11RX

Authors
BERTRAM EM ATTRIDGE SR KOTLARSKI I
Citation
Em. Bertram et al., IMMUNOGENICITY OF THE ESCHERICHIA-COLI FIMBRIAL ANTIGEN K99 WHEN EXPRESSED BY SALMONELLA-ENTERITIDIS 11RX, Vaccine, 12(15), 1994, pp. 1372-1378
Citations number
31
Categorie Soggetti
Immunology
Journal title
Vaccine → ACNP
ISSN journal
0264410X
Volume
12
Issue
15
Year of publication
1994
Pages
1372 - 1378
Database
ISI
SICI code
0264-410X(1994)12:15<1372:IOTEFA>2.0.ZU;2-L
Abstract
Salmonella strains expressing the Escherichia coli fimbrial protein K9 9 were used to immunize adult mice, and the resulting anti-K99 T-cell responses were examined. Immunized animals displayed delayed-type hype r sensitivity responses when challenged with K99 in the footpad. Lymph oid cells from immunized animals proliferated and released cytokines w hen cultured in vitro with K99 or peptides generated by cyanogen bromi de treatment; the T cells which responded had the CD4+ phenotype.