ADJUVANT QUIL-A IMPROVES PROTECTION IN MICE AND ENHANCES OPSONIC CAPACITY OF ANTISERA INDUCED BY PNEUMOCOCCAL POLYSACCHARIDE CONJUGATE VACCINES

Authors
ALONSODEVELASCO E DEKKER HAT ANTAL P JALINK KP VANSTRIJP JAG VERHEUL AFM VERHOEF J SNIPPE H
Citation
E. Alonsodevelasco et al., ADJUVANT QUIL-A IMPROVES PROTECTION IN MICE AND ENHANCES OPSONIC CAPACITY OF ANTISERA INDUCED BY PNEUMOCOCCAL POLYSACCHARIDE CONJUGATE VACCINES, Vaccine, 12(15), 1994, pp. 1419-1422
Citations number
16
Categorie Soggetti
Immunology
Journal title
Vaccine → ACNP
ISSN journal
0264410X
Volume
12
Issue
15
Year of publication
1994
Pages
1419 - 1422
Database
ISI
SICI code
0264-410X(1994)12:15<1419:AQIPIM>2.0.ZU;2-9
Abstract
The adjuvant effect of Quil A on the primary antibody response of mice to pneumococcal capsular polysaccharide conjugates was examined. Quil A increased the anti-capsular polysaccharide antibody titres, the pro tection against Streptococcus pneumoniae, and the opsonic capacity of the antibodies as measured in a newly developed in vitro phagocytosis assay, using the mouse macrophage cell line J774.