CATALYTIC HYDROXYL AMINE DYADS WITHIN SERINE PROTEASES/

Authors
PAETZEL M DALBEY RE
Citation
M. Paetzel et Re. Dalbey, CATALYTIC HYDROXYL AMINE DYADS WITHIN SERINE PROTEASES/, Trends in biochemical sciences, 22(1), 1997, pp. 28-31
Citations number
33
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
22
Issue
1
Year of publication
1997
Pages
28 - 31
Database
ISI
SICI code
0968-0004(1997)22:1<28:CHADWS>2.0.ZU;2-D
Abstract
The 'catalytic triad' mechanism, which involves a serine, histidine an d aspartic acid, has become synonymous with serine proteases. However, recently, mechanistically novel serine proteases have been discovered . These proteases use hydroxyl/epsilon-amine or hydroxyl/alpha-amine ' catalytic dyads' as their reactive centers.