NEW CHIRAL DICHLOROPHOSPHINES AND THEIR USE IN THE SYNTHESIS OF PHOSPHETANE OXIDES AND PHOSPHINIC CHLORIDES

Myrtanyl-, bornyl- and isopinocampheyldichlorophosphines have been pre pared from the corresponding alkyl chlorides via diastereospecific rea ctions of the Grignard reagents with PCl3 or (Et(2)N)(2)PCl. Two appli cations of these compounds to synthetic asymmetric organophosphorus ch emistry have been examined: their reactions with 2,3,3-trimethylbutene and AlCl3 afford either P-chiral phosphetane oxides or, in the presen ce of gaseous HCl, P-chiral phosphinic chlorides with moderate to high diastereoselectivity.