SYNTHESIS OF 10,11-DIHYDRO-12-OXO-LTB(4), A KEY BIOCHEMICAL INTERMEDIATE

Authors
KHANAPURE SP WANG SS POWELL WS ROKACH J
Citation
Sp. Khanapure et al., SYNTHESIS OF 10,11-DIHYDRO-12-OXO-LTB(4), A KEY BIOCHEMICAL INTERMEDIATE, Journal of organic chemistry, 62(2), 1997, pp. 325-330
Citations number
49
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
62
Issue
2
Year of publication
1997
Pages
325 - 330
Database
ISI
SICI code
0022-3263(1997)62:2<325:SO1AKB>2.0.ZU;2-6
Abstract
The first total synthesis of the 0,11-dihydro-12-oxo-6(Z),8(E),14(Z)-e icosatrienoic acid (10,11-dihydro-12-oxo-LTB(4)) (3) is reported. This compound is a key pivotal intermediate in the biotransformation of LT B(4) by the so-called ''LTB(4) reductase pathway''.