TISSUE-TYPE PLASMINOGEN-ACTIVATOR (TPA) IS THE MAIN PLASMINOGEN-ACTIVATOR ASSOCIATED WITH ISOLATED RAT NERVE GROWTH CONES

Authors
GARCIAROCHA M AVILA J ARMASPORTELA R
Citation
M. Garciarocha et al., TISSUE-TYPE PLASMINOGEN-ACTIVATOR (TPA) IS THE MAIN PLASMINOGEN-ACTIVATOR ASSOCIATED WITH ISOLATED RAT NERVE GROWTH CONES, Neuroscience letters, 180(2), 1994, pp. 123-126
Citations number
36
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
180
Issue
2
Year of publication
1994
Pages
123 - 126
Database
ISI
SICI code
0304-3940(1994)180:2<123:TP(ITM>2.0.ZU;2-R
Abstract
Different studies in tissue culture have shown the involvement of plas minogen activators (PAs) in nerve growth-cone migration. We have studi ed PA activity associated with isolated rat brain growth cones. Fibrin -agarose zymographies show that tissue-type PA (tPA) is the main PA as sociated with these structures. After fractionation of growth cones, a slightly higher tPA activity was found associated with the particulat e fraction. The present findings support the requirement of this prote ase for neurite growth.