SYNTHESIS AND HYDROGENATION OF 1-METHYLENECARBAPENAM

Authors
ROLAND S SAVIGNAC M DURAND JO GENET JP
Citation
S. Roland et al., SYNTHESIS AND HYDROGENATION OF 1-METHYLENECARBAPENAM, Bulletin de la Societe chimique de France, 133(10), 1996, pp. 945-950
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear",Biology,Chemistry
Journal title
Bulletin de la Societe chimique de France → ACNP
ISSN journal
00378968
Volume
133
Issue
10
Year of publication
1996
Pages
945 - 950
Database
ISI
SICI code
0037-8968(1996)133:10<945:SAHO1>2.0.ZU;2-1
Abstract
A stereoselective synthesis of a bicyclic 1,beta-methyl intermediate p recursor of 1 beta-methylcarbapenem antibiotics has been developed fro m 4-acetoxyazetidin-2-one using a pi-allyl palladium ring closure stra tegy and stereoselective hydrogenation.