THYMOMA - A STUDY OF 60 CASES IN SINGAPORE

Of 60 cases of thymomas studied in Singapore between 1988 and 1992, th e histogenetic classification proposed by Muller-Hermelink was success fully applied to subtype 58 cases, There were 20 (33%) cortical, six ( 10%) predominantly cortical, three (5%) medullary and 12 (20%) mixed t hymomas, Twelve (20%) cases were well differentiated thymic carcinomas and five (8%) were classified as other thymic carcinomas, The patholo gical and clinical features are presented in detail, These subtypes sh owed significant correlation with invasive behaviour (stage) and myast henia gravis, We conclude that the Muller-Hermelink classification has predictive utility and represents a major step towards the understand ing of the biology of thymic epithelial tumours.