IMMUNOPHYSIOLOGY - THE IMMUNE-SYSTEM AS A MULTIFUNCTIONAL PHYSIOLOGICAL UNIT

In this review, the immune system is described as a physiological syst em in its functions and relations with other organs. Hence, communicat ions are mediated by common receptors and cytokines. The immunophysiol ogy is a bidirectional system where the immune system is influenced by endocrine apparatus and vice versa. At the cellular level, we have at tempted to define this ''cross-talk'' by proposing one- or two-signal models, where the first signal is mediated via binding of hormones or neurohormones to the lymphocytes and the second signal is generated by binding of the antigen to the recognition sites or of cytokines to th eir lymphocyte receptors. The physiological reality of these interrela tionships is discussed.